The word “glia” comes from the Greek for “glue”, reflecting their traditional role as the brain’s support cells. However, neuron–glia interactions are now recognized as essential for maintaining neural circuit function and overall brain health. My research seeks to understand how bidirectional communication between neurons and glial cells—particularly astrocytes and oligodendrocyte lineage cells—shapes both physiological and pathological brain states.

During my Ph.D. under Prof. Chong Liu at Zhejiang University, I focused on interactions between neurons and oligodendrocyte lineage cells. I discovered that neuronal activity can drive the progression of oligodendrocyte lineage cell-derived high-grade glioma. Using sophisticated mouse genetic models, I demonstrated that sensory-driven neural activity, such as olfaction, regulates gliomagenesis via IGF1 signaling, revealing a novel link between normal brain function and cancer development.

As a postdoctoral researcher in Prof. Baljit S. Khakh’s lab at UCLA, I investigate how the intricate astrocyte morphology contributes to their function and regulates local circuits in vivo. I developed astrocyte-specific genetic tools to manipulate their structure and acquired expertise in two-photon imaging of awake, behaving mice. Using these approaches, I aim to reveal fundamental principles of how astrocytes shape neural circuits and support brain function.

Research Interests

• Developing and implementing novel tools to study glial cells
• Investigating glia–neuron interactions in physiological states
• Exploring glia–neuron interactions in disease states and identifying potential therapeutic targets